Bumbo: Will spawn a level 1 Bumbo regardless of the original Bumbo's current level.Buddy in a Box: Creates another randomly generated familiar, rather than copying the same one.However, multiple white flies cannot be spawned, so using Box of Friends after taking damage or using it multiple times in a room creates no effect. Best Bud: If used before taking damage, the white fly will circle Isaac.Abyss: Flies gained from Abyss do not count as familiars for Box of Friends, and are not copied.Dead Cat: No longer copies the familiar either.1up! / Dead Cat: Familiars are multiplied but do not give Isaac additional lives.?'s Soul / Dead Bird / Eve's Bird Foot / Isaac's Head / Scissors: These familiars are not copied.Multiple twisted pairs will line up horizontally, covering a broader area. Twisted Pair: Creates additional Twisted Pairs with the same tear modifiers as the player.Smart Fly: Very useful on Greed mode, as using it will add an attacking fly, killing enemies and bosses very quickly.This process can be repeated to make Isaac near-invincible.Lil Dumpy: Will copy Lil Dumpy, adding an extra charge to Lil Dumpy's Holy Mantle-like protection.Incubus: Creates additional Incubus familiars, which share the same tear modifiers as the player.Daddy Longlegs: Familiar will be copied.Charged Baby: All around useful, can charge box of friends mid room to spawn more of itself creating a charging loop.Car Battery: Adds two copies of each familiar.After creating a wisp, Box of Friends also gives temporary copies of all of Isaac's wisps, including any extra copies Box of Friends made. Book of Virtues: Spawns black wisps on the middle ring.Bob's Brain: When used upon entering a room, Box of Friends eliminates the item delay, which allows Isaac to launch Bob's Brain immediately.Blood Puppy: Tames an angry Blood Puppy and spawns another temporary one.Cubes of Meat from Potato Peeler cannot be duplicated or upgraded. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements. Ball of Bandages / Cube of Meat / Potato Peeler: Upgrades the cube/ball for the current room.The item will cost 10 cents if found in a Shop.If Isaac has only unique familiars, a Demon Baby is spawned. Familiars with the uniquefamiliar item tag are ignored by Box of Friends.Many familiars can be spawned in Greed mode and Boss Rush, as completing waves charges the item.
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